Nathan RG, Robinson D, Cherek DR, Davison S, Sebastian S, Hack M.
Long-Term Benzodiazepine Use and Depression.
American Journal of Psychiatry 1985; 142: 144-145.

" A 1979 household survey found that 1,6 % of the adults in the United States (approximately 2.5 million people) had used antianxiaty agents daily for 1 year or more. Withdrawal symptoms following discontinuation of these agents have been studied, but little is known about the effects of long-term use." [p. 144]

" Our findings strongly support the need for increased epidemiological research with long-term
users of benzodiazepines. Continuing medical education has emphasised the importance of the
differential diagnosis of depression and anxiety disorders. Our findings suggest that patients using
the drug for more than 1 year should be reassessed for depressive disorders. " [p. 145]
[Key words; addiction, dependence, abuse, depression, long-term effects]

Nerenz K.
[ A Case of Grand-Mal Seizures Following Withdrawal of Valium.] German
Nervenarzt 1974; 45: 384-386.

" Eine erhöhte Wachsamkeit in Klinik und Praxis und genauere Analysen der Fälle von
Valiummissbrauch und -sucht sind erforderlich; dazu möchten wir mit diesem Beitrag anregen.
Soviel lässt sich aber schon jetzt mit Sicherheit feststellen: die Zunahme von Valium-Missbrauch
und Valiumsucht und die Schwere des Entzugssyndroms zeigen, dass vor einer bedenkenlosen
Langzeitverordnung dieses Medikamentes dringend zu warnen ist. " [p. 386]

[Key words; Valium, diazepam, addiction, abuse, dependence, withdrawal, detoxification]

Noyes R, Clancy J, Coryell WH, Crowe RR, Chaudhry DR, Domingo DV.
A Withdrawl Syndrome after Abrupt Discontinuation of Alprazolam.
American Journal of Psychiatry 1985; 142: 114-116.

A patient who received therapeutic doses of alprazolam for 8 weeks experienced a withdrawal
syndrome beginning 18 hours after its abrupt discontinuation. Short-acting and minimally sedating
benzodiazepines may have increased potential for withdrawal reactions. [\ABSTRACT p. 114]

[Key words; Xanax, alprazolam, addiction, dependence, withdrawal]

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